P 190 Corneal endothelial toxicity of mitomycin C in rabbits

Hsldw S.A.1, Buh~r~~nly J.1, Haswll P.D.1, Bowbr I.C.J.W.2, Bmn A.J.1 1 Depatlmenl of Ophthalmology, University ot Oxford. 2 Department of Bacterioboy. Oxford Regional FMii Heaith Laboratory. Purpose: lntravitreal antibiotic is the mainstay of endophthalmitis treatment. Repeat injections should be based on the knowledege of tissue levels. The purpose of this study is to assess the value of aqueous and vitreous assay. Methods: Aqueous and vitreous were assayed for antibiotic at the time of reinjection of 5 patients with endophthalmitis. Most patients recieved vancomydn 2 mg and amikacin 0.4 mg : one recieved amikacin 1 mg and another vancomycin 1 mg. In one patient the injection was repeated at 24 hours and in 3, at 48 hours. One patient received 3 injections. Results: Aqueous vancomycin varied from 6.4 to 90 mg / L,